A Double-Switch Vector System Positively Regulates Transgene Expression by Endogenous microRNA Expression (miR-ON Vector)
نویسندگان
چکیده
منابع مشابه
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.
RNAi is proving to be a powerful experimental tool for the functional annotation of mammalian genomes. The full potential of this technology will be realized through development of approaches permitting regulated manipulation of endogenous gene expression with coordinated reexpression of exogenous transgenes. We describe the development of a lentiviral vector platform, pSLIK (single lentivector...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2013
ISSN: 1525-0016
DOI: 10.1038/mt.2013.12